Israeli air strikes in the heart of Gaza City on Sunday killed at least 23 people and wounded 50, Gaza Health Ministry said.
It was the deadliest single attack since the start of heavy fighting between Israel and Gaza’s militant Hamas rulers nearly a week ago.
Earlier, Israel said it bombed the home of Gaza’s top Hamas leader in a separate strike, the third such strike targeting the homes of Hamas leaders.
In the aftermath, sirens warning of rocket attacks sounded in Israeli border towns shortly after dawn as hostilities stretched into a seventh day with no sign of abating.
At least 153 people have been killed in Gaza since Monday, including 42 children, health officials said.
Israel has reported 10 dead, including two children.